Real people compare Quark and InDesign at Ask MetaFilter.
Some representative comments:
The paragraph styles are just incredibly thorough. You can adjust nearly every possible aspect of a paragraph imaginable. When laying out books, I usually have about 6 major styles (title, heading, subheading, normal text, list text and quote text). Then you can dump your text from wherever. Copy, paste. Copy, paste. Then just highlight the areas and apply the styles. BAM! It's all consistent. K-rad.And:
I second the InDesign recommendations. Quark definitely has a lot of staying power since it was so dominant but with the CS version of InDesign I've witnessed an enthusiastic shift (though of course what I witness and what is happening industry wide could be completely different.)